Professor and Director of the Neuroscience Program in the College of Liberal Arts

823 Weiss Hall
Philadelphia, Pennsylvania 19122



Neurobiology, Learning, Addiction, Nicotine, Hippocampus


Thomas J. Gould, Ph.D. is a Professor of Psychology at Temple University, the Director of the College of Liberal Arts Program in Neuroscience, and head of the Neurobiological Investigations of Learning & Addiction (NILA) lab. He is also a member of the Temple University Neuroscience Program. In addition to affiliations with the psychology department and the neuroscience program, Dr. Gould has a secondary appointment in the Center for Substance Abuse Research (CSAR) at the Temple University School of Medicine, and he is also an investigator and member of the Center for Interdisciplinary Research on Nicotine Addiction at the University of Pennsylvania. Dr. Gould received his BS in Psychology from the University of Wisconsin and his Ph.D. in Psychology and in Neuroscience from Indiana University.

Dr. Gould won the 2012 Temple University Eberman Faculty Research Award, the 2010 Lindback Award for Distinguished Teaching, and the 2004 Temple University ATTIC Distinguished Teaching Award. He is the author of over 100 scholarly manuscripts, and his research is currently funded by the National Institute on Drug Abuse (NIDA) and the National Cancer Institute (NCI). Dr. Gould is a member of the Society for Neuroscience, the Society for Research on Nicotine and Tobacco, the Research Society on Alcoholism, the College on Problems of Drug Dependence, and the Pavlovian Society. Dr. Gould is the President-Elect for the Society for Research on Nicotine and Tobacco, the Chair of NIH/CSR Study Section Neurobiology of Motivated Behavior, and a Senior Editor for the journal Neuropharmacology.

His current research interest is in the neurobiology of learning and memory with a specific focus on identifying the cellular and molecular events that underlie the effects of drugs of abuse, such as nicotine, on learning and memory. To that end, the NILA lab uses neurobiological, behavioral, pharmacological, genetic, and molecular techniques to investigate the effects of drugs of abuse on learning, with a specific emphasis on how those effects change as drug administration transitions from acute to chronic drug use, and then to withdrawal. Current projects in the lab include an examination of the effects of nicotine on hippocampus functioning and hippocampus-dependent learning. This research also examines genetic and developmental factors that may contribute to the effects of nicotine on cognitive processes.

Selected Publications

Peer-Reviewed Manuscripts from 2012-2013 (* denotes graduate student, • denotes undergraduate student)
Logue, S.F. and Gould, T.J. The Neural and Genetic Basis of Executive Function: Attention, Cognitive Flexibility, and Response Inhibition. Pharmacology, Biochemistry and Behavior, in press.

Gould, T.J. and Leach, P.T.* Cellular, Molecular, and Genetic Substrates Underlying the Impact of Nicotine on Learning. Neurobiology of Learning and Memory, in press.

Logue, S.F., Chein, J., Gould, T.J., Holliday, E.* and Steinberg, L. Adolescent Mice, Unlike Adults, Consume More Alcohol in the Presence of Peers Than Alone. Developmental Science, in press.

Wilkinson, D.S.* and Gould, T.J. Withdrawal from chronic nicotine and subsequent sensitivity to nicotine challenge on contextual learning. Behavioural Brain Research, in press.

Turner, J.L., Wilkinson, D.S.*, Poole, R.L.*, Gould, T.J., Carlson, G.C., and Blendy, J.A. Divergent Functional Effects of Sazetidine-A and Varenicline during Nicotine Withdrawal. Neuropsychopharmacology, in press.

Lotfipour, S., Byun, J., Leach, P.*, Fowler, C., Murphy, N., Kenny, P., Gould, T.J. and Boulter J. (2013) Targeted Deletion of the Mouse 2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors. Journal of Neuroscience, 33(18):7728-41.

Leach, P.T.*, Cordero, K.A.•, and Gould, T.J. (2013) The Effects of Acute, Chronic, and Withdrawal from Chronic Nicotine on Performance of a Cued Appetitive Response. Behavioral Neuroscience, 127:303-10.

Ortega, L.A., Tracy, B.A.•, Gould, T.J., Parikh, V. (2013) Effects of Chronic Low- and High-Dose Nicotine on Cognitive Flexibility in C57BL/6J Mice. Behavioural Brain Research, 238:134-45.

Wilkinson, D.S.*, Turner, J.L., Blendy, J.A., and Gould, T.J. (2013) Genetic Background Influences the Effects of Withdrawal from Chronic Nicotine on Learning and High-Affinity Nicotinic Acetylcholine Receptor Binding in the Dorsal and Ventral Hippocampus. Psychopharmacology, 225(1):201-8.

Twyman, A.*, Newcombe, N.S., and Gould, T.J. (2013) Malleability in the Development of Spatial Reorientation. Developmental Psychobiology, 55(3):243-55.

Kenney, J.W.*, Raybuck, J.D.*, and Gould, T.J. (2012) Nicotinic Receptors in the Dorsal and Ventral Hippocampus Differentially Modulate Contextual Fear Conditioning. Hippocampus, 22(8):1681-90.

Leach, P.T.*, Poplawski, S.G.*, Kenney, J.W.*, Liebermann, D.A., Hoffman, B., Abel, T. and Gould, T.J. (2012) Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory. Learning &Memory, 19(8):319-24.

Kenney, J.W.*, Poole, R.L.*, Adoff, M.D., Logue, S.F., and Gould, T.J. (2012) Learning and Nicotine Interact to Increase CREB Phosphorylation at the jnk1 Promoter in the Hippocampus. PLoS ONE, 7(6):e39939.

Portugal, G.S.*, Wilkinson, D.S.*, Turner, J.R., Blendy, J.A., and Gould, T.J. (2012) Developmental Effects of Acute, Chronic, and Withdrawal from Chronic Nicotine on Fear Conditioning. Neurobiology of Learning and Memory, 97(4):482-94.

Gould, T.J., Portugal, G.*, André, J.M.*, Tadman, M.P., Marks, M.J., Kenney, J.W.*, Yildirim, E., Adoff, M. (2012) The Duration of Nicotine Withdrawal-Associated Deficits in Contextual Fear Conditioning Parallels Changes in Hippocampal High Affinity Nicotinic Acetylcholine Receptor Upregulation. Neuropharmacology, 62(5-6):2118-25

André, J.M.*, Cordero, K.A. •, and Gould, T.J. (2012) Comparison of the Performance of DBA/2 and C57BL/6 Mice in Transitive Inference and Foreground and Background Contextual Fear Conditioning. Behavioral Neuroscience, 126(2):249-57.

Portugal, G.S.*, Wilkinson, D.S.*, Kenney, J.W.*, Sullivan, C. •, and Gould, T.J. (2012) Strain-dependent Effects of Acute, Chronic, and Withdrawal from Chronic Nicotine on Fear Conditioning. Behavioural Genetics, 42:133-50.

Courses Taught

Behavioral Neuroscience
Neurobiology of Learning and Memory
Capstonse Course in Neuroscience